L-(+)-serine 3-(dihydrogen phosphate)
O-phospho-L-serine
CAS: 407-41-0
Molecular Formula: C3H8NO6P
L-(+)-serine 3-(dihydrogen phosphate) - Names and Identifiers
| Name | O-phospho-L-serine |
| Synonyms | dexfosfoserine L-PHOSPHOSERINE H-Ser(PO3H2)-OH H-SER(PO3H2)-OH Phospho-L-serine L-O-PHOSPHOSERINE O-Phosho-L-serine L-O-Phosphoserine O-phospho-L-serine L-Serine phosphate O-Phosphorylserine O-phosphono-L-serine L-SERINE-O-PHOSPHATE Phosphoserinebariumsalt MDI Polyols for PU Foams L-Phosphoserine Anhydrous DL-O-Phosphoserine barium salt PHOSPHATIDYLETHANOLAMINE(EGG)(RG) L-(+)-serine 3-(dihydrogen phosphate) (2S)-2-ammonio-3-(phosphonatooxy)propanoate |
| CAS | 407-41-0 |
| EINECS | 206-986-0 |
| InChI | InChI=1/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/p-2/t2-/m0/s1 |
| InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N |
L-(+)-serine 3-(dihydrogen phosphate) - Physico-chemical Properties
| Molecular Formula | C3H8NO6P |
| Molar Mass | 185.07 |
| Density | 1.809±0.06 g/cm3(Predicted) |
| Melting Point | 190°C(lit.) |
| Boling Point | 475.4±55.0 °C(Predicted) |
| Specific Rotation(α) | [α]D20 +14～+18°(c=5,dil.HCl) |
| Flash Point | 241.3°C |
| Water Solubility | 28.34g/L at 20℃ |
| Solubility | H2O: 50mg/mL hot, clear, colorless to slightly yellow |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | Crystalline Powder |
| Color | White |
| Merck | 14,7363 |
| BRN | 1726826 |
| pKa | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) |
| Storage Condition | under inert gas |
| MDL | MFCD00065935 |
| In vitro study | O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina. |
L-(+)-serine 3-(dihydrogen phosphate) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 21/22 - Harmful in contact with skin and if swallowed. |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 3261 8 / PGII |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29225090 |
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